Publications
Polymorphism of Drugs and the Problem of Creation of a New Generation of Pharmacological Agents
- The strategy of the search and development of new stereoselective drugs
- History of the development of the concept of polymorphism of chemical materials
- Stabilization of nonequilibrium conformers of an organic material in solutiondue to their association and subsequent solvation
- The investigation of the structure of polymorphous forms of 6-methyluracil by methods of quantum chemistry and molecular mechanics
- Physicochemical aspects of obtaining polymorphous modifications of drugs
- Granulometric composition and biononequivalence of barbital
- The investigation of diffusion properties of solutions of polymorphous modifications of 6-methyluracil
- Physicochemical properties of leocaine and features of its biological activity in a comparative aspect with dicain
- Pharmacodynamic characteristics of tetracaine and its metastable β-modification, leocaine, as agents of local anesthesia in ophthalmology
- A comparative study of leocaine and tetracaine as spinal anesthetics
- The effect of leocaine on excitability of the mycardium, exchange of ions, and membrane potentials of cardiomyocytes
- Structural features, physicochemical properties, and biological activity of betamecil on a comparative plane with methyluracil
- Features of molecular mechanisms of the biological activity of betamecil and methyluracil
- Betamecil as a stimulator of reparative regeneration of the cornea of the eye
- The effect of betamecil on the course of tuberculosis and sarcoidosis (experimental investigation)
- The effect of betamecil and methyluracil on dimensions of necrosis zones and reparative processes during an experimental infarct of the myocardium
- System of quick methods of integral evaluation of the biological activity of individual materials and complex preparations on biological objects
- Dry plant extracts – new technology, new quality
- Analysis and standardization of drugs, obtained by the method of polymorphous modification
- The problem of patent protection of individual polymorphous modifications of drugs
- The role of economic factors in the creation of new drugs
We believe that due to this slight nonplanar structure of ligand and presence of more number of C-H⋯O interactions in C2 (conformational polymorph of Cu(II) with 1,2,4-triazolo[1,5-a]
Influence of changes in molecular conformation on the formation and stability of polymorphic forms
Advances in understanding of polymorphism from a structural point of view: new technologies for controlling polymorphic forms
Analysis of all polymorphic compounds from the Cambridge Structural Database (CSD) and demonstration of polymorphism variations
The effect of the solvent on the formation of polymorphic forms of pharmaceutical ingredients
Discovery of new polymorphic forms of active pharmaceutical ingredients
Technologies for the intensification of the process of obtaining medical substances and polymorphic control in the continuous production of active pharmaceutical ingredients
Review of publications investigating and using the phenomenon of polymorphism
Investigation of polymorphic behavior in pharmaceutical development: solvatomorphism and its thermodynamic and structural origin