git Anticoagulant – SmartPolymorph

Anticoagulant

INN: -

New modifications L, U, as well as a DMSO solvate with improved pharmacological properties

Medical form
New modification
New modification
New modification
DSC curve
X-ray diffraction
Raman spectra
Solubility
Solubility
Inhibition of Xa factor
Inhibition of Xa factor
Thrombin generation test

Three new substances were obtained: two new metastable modifications and solvate with DMSO

Increased solubility by 3-5 times

Specific activity in inhibiting Xa factor increased by 2-3 times