Services
Available list of services on the developed polymorphic modification
SOLID PHASE:
- X-ray diffraction
- Differential scanning calorimetry, DSC+TGA
- FTIR
- Raman spectroscopy
- Scanning electron microscopy
- Elemental analysis
- Surface area
SOLUTION:
- 1Н- and 13С-NMR Spectrophotometry
- Polarimetry
- Static and dynamic light scattering
- Circular dichroism
- HPLC
Comparison of the specific activity of polymorphic modifications in vitro and in vivo, development of the study design
- Stability study of the polymorphic forms and solvates
- Photostability study
- The accelerated stability tests are performed in a certified Memmert climatic chamber under standard conditions at 40°C, 75% humidity. Other conditions are negotiated with customers
The solubility and dissolution rate tests are performed by quantitative spectrophotometry and HPLC
- The co-crystallization process is carried out to increase the solubility of the pharmaceutical substance and new patent protection
- Co-crystallization with active substances
- Co-crystallization with excipients
Any pharmacologically acceptable counter - ions in the salt are possible for synthesis and technology application (hydrochlorides, hydrobromides, sulfates, carbonates, nitrates, tartrates, acetates, esylates, succinates, maleate, etc.)
Scale up and manufacturing of a certain polymorphic form of a pharmaceutical substance for passing registration procedures and further production of the drug
- Patent search
- Preparation of a patent application based on the physical and chemical properties, solubility and specific activity of polymorphic forms
Advising on the choice of the optimal way to register a drug with new polymorphic form based on its physico-chemical and biological properties