git Services – SmartPolymorph


Development of polymorph modifications of well-known successful drugs to improve their properties, as well as to extend or renew patent protection
Development of polymorph modifications of new compounds that did not show the expected results in clinical studies to improve pharmacological properties and possible repositioning

Available list of services on the developed polymorphic modification


  • X-ray diffraction
  • Differential scanning calorimetry, DSC+TGA
  • FTIR
  • Raman spectroscopy
  • Scanning electron microscopy
  • Elemental analysis
  • Surface area


  • 1Н- and 13С-NMR Spectrophotometry
  • Polarimetry
  • Static and dynamic light scattering
  • Circular dichroism
  • HPLC

Comparison of the specific activity of polymorphic modifications in vitro and in vivo, development of the study design

  • Stability study of the polymorphic forms and solvates
  • Photostability study
  • The accelerated stability tests are performed in a certified Memmert climatic chamber under standard conditions at 40°C, 75% humidity. Other conditions are negotiated with customers

The solubility and dissolution rate tests are performed by quantitative spectrophotometry and HPLC

  • The co-crystallization process is carried out to increase the solubility of the pharmaceutical substance and new patent protection
  • Co-crystallization with active substances
  • Co-crystallization with excipients

Any pharmacologically acceptable counter - ions in the salt are possible for synthesis and technology application (hydrochlorides, hydrobromides, sulfates, carbonates, nitrates, tartrates, acetates, esylates, succinates, maleate, etc.)

Scale up and manufacturing of a certain polymorphic form of a pharmaceutical substance for passing registration procedures and further production of the drug

  • Patent search
  • Preparation of a patent application based on the physical and chemical properties, solubility and specific activity of polymorphic forms

Advising on the choice of the optimal way to register a drug with new polymorphic form based on its physico-chemical and biological properties